GSTM1, GSTT1 and CYP1A1 polymorphism and risk of oral cancer: a case-control study in Jakarta population,Indonesia

Amtha, R. and IA, Razak and RB, Zain (2009) GSTM1, GSTT1 and CYP1A1 polymorphism and risk of oral cancer: a case-control study in Jakarta population,Indonesia. pp. 1-4.

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Abstract

<p align="justify"><font face="Arial"><strong>Rahmi Amtha, Cheong Sok Ching, Rosnah Zain, Ishak Abdul Razak, Bastaman Basuki, Boedi Oetomo Roeslan, Walta Gautama, Denny&nbsp; Purwanto</strong></font></p> <p align="justify"><font face="Arial">Purpose: to investigate genetic polymorphisms in GSTM1, GSTT1 and CYP1A1 and the association with the risk of oral cancer in the Jakarta population. Method: A total of 81 cases and 162 controls matched for age and sex were selected from 5 hospitals in Jakarta. Sociodemographic data using questionnaires were obtained and peripheral blood samples were collected with informed consent for PCR-RFLP assay. Conditional logistic regression analysis was performed to obtain the association between the risk of oral cancer and GSTM1, GSTT1 and CYP1A1 polymorphisms. Results: GSTM1 and GSTT1 null were slightly overrepresented among cases (60.5% and 45.7% respectively) compared to controls (55.6% and 41.4% respectively), but no statistically significant differences were observed. In contrast, the distribution of CYP1A1 polymorphism was higher among controls compared to cases (52.5 % versus 42.4 %). The odds ratio of null GSTM1 and GSTT1 genotypes was slightly higher compared to wild type genotypes (OR 1.19, 95% CI 0.70-2.02 and OR 1.19, 95% CI 0.72-2.05 respectively). Furthermore, the presence of CYP1A1 polymorphism did not increase the risk of oral cancer (OR 0.70, 95% 0.39-1.25). Conclusion: Genetic polymorphisms of GSTM1, GSTT1 and CYP1A1 may not be risk factors for oral cancer in the Jakarta population.</font></p> <p align="justify"><font face="Arial">Asian Pacific J Cancer Prev 2009; 10: 21-26</font></p>

Item Type: Article
Uncontrolled Keywords: oral cancer risk, metabolizing enzymes polymorphism, Jakarta Indonesia
Subjects: R Medicine > RK Dentistry
Depositing User: MR. ADNAN YAHYA
Date Deposited: 19 May 2009
Last Modified: 18 Dec 2009
URI: http://repository.um.edu.my/id/eprint/73038

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